Research progress on mitochondrial SIRTs involved in neurodegenerative diseases
10.3969/j.issn.1005-4847.2025.09.012
- VernacularTitle:线粒体SIRTs在神经退行性疾病中的研究进展
- Author:
Jinjin WAN
1
;
Yanling YIN
1
;
Limin LIU
1
Author Information
1. 首都医科大学基础医学院,北京 100069
- Publication Type:Journal Article
- Keywords:
neurodegenerative diseases;
mitochondrion;
SIRTs;
neuronal degeneration
- From:
Acta Laboratorium Animalis Scientia Sinica
2025;33(9):1373-1380
- CountryChina
- Language:Chinese
-
Abstract:
Neurodegenerative diseases are a group of disorders characterized by chronic progressive degeneration of neurons in the brain and/or spinal cord.Their etiology remains unclear,the pathogenesis is complex,and no effective treatments exist.Importantly,the roles of mitochondria-localized silent information regulator(SIRT)family members,including SIRT3,SIRT4,and SIRT5,in neurodegenerative diseases are attracting increasing attention.Accumulating evidence demonstrates their involvement in critical processes of neuronal degeneration by regulating,for example,mitochondrial function and inflammatory responses.This review summarizes the research advances on mitochondrial SIRTs in neurodegenerative diseases such as Alzheimer's disease,Parkinson's disease,and amyotrophic lateral sclerosis,and aims to provide new insights for elucidating disease pathogenesis and developing prevention/therapeutic strategies.
