Research progress on the effect and mechanism of natural products of traditional Chinese medicine in preventing vascular restenosis
10.12092/j.issn.1009-2501.2025.10.013
- VernacularTitle:中药天然产物预防血管再狭窄的作用及机制研究进展
- Author:
Jiawei LUO
1
;
Tianwang CHEN
;
Xinyu WANG
;
Juan LIU
;
Bo HUANG
;
Lisheng LI
;
Shangfu XU
Author Information
1. 遵义医科大学基础药理教育部重点实验室暨特色民族药教育部国际合作联合实验室,遵义 563000,贵州
- Publication Type:Journal Article
- Keywords:
natural products of traditional Chi-nese medicine;
vascular restenosis;
vascular smooth muscle cell;
mechanism of action;
research progress
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(10):1408-1416
- CountryChina
- Language:Chinese
-
Abstract:
Percutaneous coronary intervention(PCI)has been widely applied in the clinical treat-ment of coronary atherosclerotic heart disease and achieved good therapeutic effects.However,vascu-lar restenosis caused by postoperative vascular re-modeling still needs attention,which seriously af-fects the long-term efficacy of PCI.The prevention of vascular restenosis is of great significance for cardiovascular diseases.Traditional Chinese medi-cine natural products,with their characteristics of multiple targets,low toxicity and high safety,have attracted increasing attention in recent years.More and more studies have found that traditional Chi-nese medicine natural products have the effect of preventing and treating vascular restenosis and can effectively control its occurrence and development.This article reviews the effects and mechanisms of flavonoids,alkaloids,terpenoids and glycosides,polysaccharides and polyphenols and other tradi-tional Chinese medicine natural products in pre-venting vascular restenosis,and analyzes and sum-marizes the differences in the effects and mecha-nisms of various natural products,providing new ideas for the development of safe and effective drugs to prevent vascular restenosis.
