Pineoblastoma in adult:a clinicopathological analysis of 11 cases
10.13315/j.cnki.cjcep.2025.09.009
- VernacularTitle:成人松果体母细胞瘤11例临床病理学观察
- Author:
Xiao FENG
1
;
Rusong ZHANG
;
Xuan WANG
;
Qunli SHI
;
Zhen YUE
Author Information
1. 南京中医药大学附属医院/江苏省中医院病理科,南京 210029
- Publication Type:Journal Article
- Keywords:
pineoblastomas;
immunohistochemistry;
differential diagnosis;
treatment
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(9):1175-1179,1186
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinical pathological features and treatment strategies of adult pineoblasto-ma(PB).Methods The clinical data of 11 cases of adult PB were retrospectively analyzed.Their imaging,histologi-cal morphology,and immunohistochemical characteristics were evaluated,and the relevant literature was reviewed.Re-sults Among the 11 PB cases,5 cases were female and 6 were male,aged 18-63 years with a median age of 39 years.Microscopically,the tumors were composed of dense small to medium-sized cells,showing a diffuse and sheet-like distribution.Rosette-like structures could be seen in some cases.The tumor cell nuclei were round or irregular with a high nuclear-cytoplasmic ratio.The mitotic figures and apoptosis were extremely common to see,and necrosis was observed in some cases.The tumor cells were uniformly positive for CD56(11/11),Syn(11/11),and CgA(11/11),with retained expression of INI-1(11/11).Some cases were positive for CD99(3/11)and S-100(1/11),while negative for BCOR,CKpan,GFAP,PLAP,CD3,and CD20.The Ki67 proliferation index ranged from 20％to 80％.Five patients were followed up for 2 to 39 months:1 patient developed spinal metastasis 26 months after postop-erative chemotherapy;1 patient had spinal metastasis 4 months after postoperative radiotherapy and temozolomide treat-ment;and 3 patients died.Conclusion PB is a rare,highly malignant tumor in the pineal gland region,even rarer in adults.Its morphology is similar to that of childhood PB,and its prognosis is slightly better than that in children.
