Influence and mediation effect of adolescent obesity on myopia risk:a cross-sectional and cohort analysis based on longitudinal study of Chengdu city from 2014 to 2023
10.12007/j.issn.0258-4646.2025.03.003
- VernacularTitle:青少年肥胖对近视风险的影响和中介效应:基于成都市2014年至2023年追踪调查的横断面和队列研究
- Author:
Yanqun WEN
1
;
Ya WEN
;
Kefeng LI
;
Lihua DI
;
Li ZHAO
;
Siqi LI
Author Information
1. 成都市成华区疾病预防控制中心卫生监测科,成都 610057
- Publication Type:Journal Article
- Keywords:
obesity;
myopia;
mediation;
blood pressure;
cohort
- From:
Journal of China Medical University
2025;54(3):204-207
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationships between adolescents'body mass index(BMI),blood pressure(BP),and myopia and provide a scientific basis for the formulation of myopia prevention and control measures.Methods Adolescent students who par-ticipated in physical fitness surveillance in Chenghua District,Chengdu,from 2014 to 2023 were selected as the study population.A cross-sectional study was conducted using multiple logistic regression,adjusting for age,sex,BP,and pulse as covariates.A Cox model was employed to examine the relationship between obesity and myopia.Additionally,for the 2023 dataset,characterized by the largest sample size and most complete data,a mediation analysis was performed with mean BP as the mediator.Results Annual cross-sectional analysis from 2014 to 2023 revealed a significant positive association between obesity and myopia,with OR and 95％CI of 1.16(1.10-1.22),1.15(1.08-1.21),1.19(1.12-1.26),1.11(1.04-1.18),1.10(1.05-1.15),1.10(1.05-1.16),1.07(1.03-1.12),1.10(1.05-1.15),1.12(1.07-1.17),and 1.11(1.06-1.15),respectively.Similarly,cohort analysis showed a significant positive association between obesity and myopia(HR=1.09,95％CI:1.01-1.19).Mediation analysis indicated that BP accounted for 21.2％of the total effect of obesity on myopia.Conclusion Obesity facilitates the onset of myopia,and weight reduction can help decrease the likelihood of latter.Furthermore,BP mediates the impact of obesity on myopia.Implementing BP-lowering interventions in obese populations may aid in the prevention of myopia.
