Characterization of blood culture strain isolation and prognosis of patients with candidemia
10.12007/j.issn.0258-4646.2025.03.006
- VernacularTitle:念珠菌血症患者血培养菌株分离特点及预后分析
- Author:
Ning JIANG
1
;
Lijie GUO
1
;
Yunzhuo CHU
1
Author Information
1. 中国医科大学附属第一医院检验科,国家医学检验临床医学研究中心,沈阳 110001
- Publication Type:Journal Article
- Keywords:
candidemia;
risk factor;
drug susceptibility test;
prognosis
- From:
Journal of China Medical University
2025;54(3):219-222,227
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics,drug sensitivity,and prognostic risk factors of patients with candidemia at our hospital,for providing evidence for rational drug use and improving prognosis.Methods A total of 181 patients with candidemia who were admitted to our hospital between January 2020 and December 2022 were selected for this study.Basic data,drug susceptibility test results,and clinical information were collected and analyzed.Patients were divided into two groups:a favorable prognosis group and a poor prognosis group;their prognostic risk factors were analyzed using univariate and binary logistic analyses.Results Candidemia was diagnosed from 181 Candida strains,including Candida parapsilosis(88 strains,48.62％),Candida albicans(34 strains,18.78％),Candida tropicalis(29 strains,16.02％),and Candida glabrata(17 strains,9.39％).Patients with candidemia were mainly diagnosed during general surgery(51.93％),intensive care unit(16.02％),and emergency department(9.94％).Univariate and binary logistic analyses showed that use of hormone and(or)immunosuppressive agents(OR=4.787),mechanical ventilation for more than 96 h(OR=4.558),renal insuffi-ciency(OR=4.426),and intrapulmonary infection(OR=4.228)were important independent risk factors.The highest detection rate of can-didemia in our hospital was for Candida parapsilosis.With the exception of Candida tropicalis,which was less sensitive to voriconazole,all other strains were sensitive to azole drugs.In conclusion,hormone and(or)immunosuppressive agents,mechanical ventilation for more than 96 h,renal insufficiency,and intrapulmonary infection are independent risk factors for poor prognosis in patients with candidemia.
