Research progress of enteric metabolites in Alzheimer's disease
10.3969/j.issn.1004-1648.2025.02.023
- VernacularTitle:肠道源性代谢产物在Alzheimer's病的研究进展
- Author:
Nian CHEN
1
;
Congcong LIU
;
Yuan LIANG
Author Information
1. 272067 济宁医学院临床医学院
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
gut microbiota;
gut-brain axis;
metabolomics
- From:
Journal of Clinical Neurology
2025;38(2):143-147
- CountryChina
- Language:Chinese
-
Abstract:
The bidirectional communication between gut microbiome and host significantly affects brain function,and there is increasing evidence that the imbalance of gut microbiota is closely related to the onset of Alzheimer's disease(AD).Blood-and gut-based metabolites,such as trimethylamine oxide,short-chain fatty acids,GABA and tryptophan metabolites,are likely to be the main mediators of the"microbiota-gut-brain axis",and play an important role in maintaining intestinal flora homeostasis and intestinal mucosal integrity,regulating the host immune system and cognitive function.This paper aims to summarize the blood and intestinal metabolites in the development of AD disease,and provide a new direction for the treatment of AD in the future.
