Role of mitophagy in Alzheimer's disease and research progress on the regulatory mechanism of traditional Chinese medicine
10.3969/j.issn.1005-4847.2025.09.011
- VernacularTitle:线粒体自噬在阿尔茨海默病的作用及中药调控机制研究进展
- Author:
Fangfang ZHAO
1
;
Yanke GUO
;
Xueke WANG
;
Botong PANG
;
Yanqiang ZHU
;
Yang QIN
;
Yinglin CUI
Author Information
1. 河南中医药大学第二临床医学院,郑州 450046
- Publication Type:Journal Article
- Keywords:
mitophagy;
Alzheimer's disease;
signal pathway;
traditional Chinese medicine;
mechanism research
- From:
Acta Laboratorium Animalis Scientia Sinica
2025;33(9):1360-1372
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondrial autophagy is a unique mechanism that selectively clears dysfunctional or excess mitochondria,closely related to Alzheimer's disease(AD),which is characterized by aggregated neurotoxic proteins and dysfunctional mitochondria.Numerous recent studies have confirmed that traditional Chinese medicine can have significant therapeutic effects against AD,and its advantages including multi-target,multi-pathway,and multi-action mechanisms have become an important component of AD research.Chinese medicine formulas and monomeric active ingredients,such as Jiannaoyizhi Fang,Danggui Shaoyao Tang,alkaloids,and flavonoids,can regulate mitochondrial autophagy-related signaling pathways and targets,inhibit neuronal mitochondrial autophagy defects,and play a neuroprotective role.This review elaborates on the basic process of mitochondrial autophagy and its related signaling pathways and molecular mechanisms in the pathogenesis of AD,and considers the latest research progress on the use of traditional Chinese medicine to improve AD by regulating mitochondrial autophagy,to provide ideas and references for future basic research and clinical treatment.
