Clinicopathological features and short-term prognosis of negative triple-biomarker hepatocellular carcinoma
10.3760/cma.j.cn115455-20241223-01157
- VernacularTitle:三联检测阴性肝细胞肝癌术后临床病理特征及短期预后分析
- Author:
Chengwei WANG
1
;
Yeming ZHOU
1
;
Wei JIANG
1
;
Yongfei HUA
1
Author Information
1. 宁波大学附属李惠利医院肝胆胰外科，宁波 315041
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Pathological conditions, signs and symptoms;
Clinical futures;
Short-term prognosis
- From:
Chinese Journal of Postgraduates of Medicine
2025;48(9):809-815
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the prognosis and influencing factors of hepatocellular carcinoma patients with negative triple-biomarker after surgery.Methods:Two hundred patients undergoing surgeries for hepatocellular carcinoma with complete clinicopathological data from Lihuili Hospital Affiliated to Ningbo University from January 2020 to December 2021 were retrospectively analyzed, and their clinicopathological features, postoperative recurrence and prognosis were analyzed.Results:Among the 200 hepatocellular carcinoma patients, 54 cases were triple-negative type, 88 cases were protein induced by vitamin K absence-Ⅱ (PIVKA-Ⅱ) type, 51 cases were alpha-fetoprotein (AFP) type and 7 cases were alpha-fetoprotein Lens culinaris aggluyinin-reactive fraction 3 (AFP-L3) type. Due to the limited cases of AFP-L3 type, patients with this type were not included in this study. The recurrence rates were 29.6% (16/54), 40.9% (36/88) and 41.2% (21/51) for tripe-negative type, PIVKA-Ⅱ type and AFP type, respectively, the corresponding median recurrence-free survival time was 25.8, 10.6 and 10.0 months, respectively, and there were statistical differences ( P<0.05). The median overall survival time of tripe-negative type, PIVKA-Ⅱ type and AFP type was 40.7, 40.0 and 36.6 months, respectively, without statistical difference ( P>0.05). Univariate analysis showed that tumor diameter, tumor differentiation degree, and capsule or were not factors affecting patients′ overall survival time after surgery. Postoperative albumin, tumor diameter, tumor differentiation degree, capsule or not, and microvascular invasion were factors affecting patients′ recurrence-free survival time after surgery. Multivariate analysis showed that low tumor differentiation and no envelope were independent risk factors for patients′overall survival time after surgery. Tumor long diameter>5 cm, low differentiation, no envelope, preoperative hypoproteinemia and non-tripe-negative type were independent risk factors for patients′ recurrence-free survival time after surgery. Conclusions:The short-term postoperative recurrence rate for triple-negative hepatocellular carcinoma is low, and the correlation with long-term prognosis remains to be evaluated.
