Tyrosine phosphatase Shp2 and acute lung injury

VernacularTitle:酪氨酸磷酸酶Shp2与急性肺损伤
Author: Haoyu JI ¹ ; Lilong QIN ¹ ; Lei ZHA ¹ ; Hanli WANG ¹ ; Yusheng CHENG ¹
Author Information

1. 皖南医学院第一附属医院呼吸与危重症医学科,芜湖 241000,安徽
Publication Type:Journal Article
Keywords: phosphatase; lung injury; pulmonary infection
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2025;30(10):1436-1440
CountryChina
Language:Chinese
Abstract: Acute lung injury(ALI)is a common critical illness caused by intrapulmonary or extra-pulmonary factors,which is accompanied by ex-tremely high morbidity and mortality.Its pathogen-esis is extremely complex and difficult to treat.Src homology 2 domain-containing protein tyrosine phosphatase(Shp2),a key cellular signal transduc-tion molecule,plays a pivotal role in the pathophys-iological processes of diverse diseases.Notably,in the context of pathogen infection,Shp2 regulates the functionality of cellular immunity,lung epitheli-al cells,and vascular endothelial cells.This review article highlights the significant role of Shp2 in the onset and progression of ALI,emphasizing its regu-lation of inflammatory response,apoptosis,and ox-idative stress.Shp2 could emerge as a novel thera-peutic target for ALI,offering valuable insights for the development of innovative drug candidates to treat this debilitating condition.