Research progress on the application of tumor-associated neutrophils in immuno-therapy for colorectal cancer
10.13315/j.cnki.cjcep.2025.09.016
- VernacularTitle:肿瘤相关中性粒细胞在结直肠癌免疫治疗中的研究进展
- Author:
Jiawei CHEN
1
;
Tiefeng JIN
Author Information
1. 延边大学医学院麻醉学系,延吉 133002
- Publication Type:Journal Article
- Keywords:
colorectal cancers;
tumor-associated neutrophils;
heterogeneity;
neutrophil extracellular traps;
neutrophil lymphocyte ratio;
immunotherapy;
literature review
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(9):1215-1220
- CountryChina
- Language:Chinese
-
Abstract:
Tumor-associated neutrophils(TANs)play a pivotal role in the immunotherapy of colorectal cancer(CRC).Within the tumor microenvironment,TANs display intricate functions,embodying both tumor-facilitating and tumor-inhibiting characteristics.TANs can be categorized into N1 type(with tumor-suppressive capabilities)and N2 type(exhibiting tumor-promoting tendencies),both of which are intimately linked to tumor progression and patient prognosis.Indicators such as the neutrophil/lymphocyte ratio(NLR)and neutrophil extracellular traps(NETs)are correlated with the prognosis of CRC.Potential targets for TANs-related immunotherapy encompass modulating their po-larization state and impeding immunosuppressive functions.The combined utilization with other immunotherapeutic mo-dalities holds the promise of augmenting the therapeutic efficacy.Notwithstanding the numerous challenges,in-depth exploration of the mechanisms underlying TANs and optimization of the treatment strategies pave novel pathways for CRC treatment in the future.
