Prognostic value of quantitative electroencephalography monitoring combined with serum CXC chemokine 16 and pentametin 3 in acute cerebral infarction
10.3760/cma.j.cn115455-20231122-00493
- VernacularTitle:定量脑电图监测联合血清CXC趋化因子16、正五聚蛋白3对急性脑梗死患者预后的预测价值
- Author:
Min CHEN
1
;
Xing WANG
;
Ming SUN
Author Information
1. 锦州医科大学研究生培养基地，锦州 121000
- Publication Type:Journal Article
- Keywords:
Brain infarction;
Electroencephalography;
CXC chemokine 16;
Pentamerin 3;
Prognosis
- From:
Chinese Journal of Postgraduates of Medicine
2025;48(2):112-115
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the prognostic value of quantitative electroencephalography(EEG) monitoring combined with serum CXC chemokine 16 (CXCL16) and pentametin 3 (PTX3) in acute cerebral infarction.Methods:A total of 110 patients with acute cerebral infarction admitted to Jiangmen Central Hospital from March 2018 to March 2023 were retrospectively selected as the study objects, at 90 d after discharge, the prognosis of the patients was assessed by the modified Rankin Scale (mRs) score and divided into two groups, including 75 cases in the good prognosis group and 35 cases in the poor prognosis group. Quantitative EEG monitoring indexes and serum CXCL16 and PTX3 levels were compared between the two groups at admission. The receiver operating characteristic (ROC) curve was used to analyze the diagnostic efficacy for poor prognosis in patients with acute cerebral infarction.Results:The levels of CXCL16 and PTX3 in the poor prognosis group were higher than those in the good prognosis group: (3.74 ± 0.59) μg/L vs. (2.58 ± 0.41) μg/L, (3.36 ± 0.67) μg/L vs. (3.01 ± 0.52) μg/L, there were statistical differences ( P<0.05). Compared with patients with good prognosis in acute cerebral infarction, the power ratio index (DTABR) level of the quantitative EEG monitoring index were higher than those in patients with a poor prognosis ( P<0.05). ROC curve analysis showed that the area under the curve of quantitative EEG monitoring combined with serum CXCL16, and PTX3 for predicting poor prognosis in patients with acute cerebral infarction was 0.911 (95% CI 0.849 - 0.974), which was higher than any single index ( P<0.05). Conclusions:The levels of DTABR, serum CXCL16 and PTX3 in patients with a poor prognosis of acute cerebral infarction were higher than those in patients with good prognosis. Quantitative EEG monitoring combined with serum CXCL16 and PTX3 had high predictive value for poor prognosis of acute cerebral infarction.
