The Mechanism of Traditional Chinese Medicine in the Treatment of Rheumatic Diseases Based on N6-methyladenosine
- VernacularTitle:基于m6A甲基化探讨中医药治疗风湿性疾病的作用机制
- Author:
Yuyao WANG
1
;
Jinlin TONG
1
;
Hong LIU
1
;
Jinghua PAN
1
;
Hongyan ZHAO
1
;
Danping FAN
1
Author Information
- Publication Type:Journal Article
- Keywords: Rheumatic diseases; N6-methyladenosine; Epigenetics; Bi syndrome; Traditional Chinese medicine
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(10):2910-2919
- CountryChina
- Language:Chinese
- Abstract: Rheumatic diseases,as a complex class of chronic immune-mediated disorders,involve interplay among genetics,environment,and immunity in their pathogenesis,which remains incompletely elucidated to date.In recent years,with the advancement of epigenetic research,particularly in the field of RNA modifications,the role of m6 A methylation in rheumatic diseases has increasingly garnered attention.Traditional Chinese medicine(TCM),as the indigenous medical system of China,has accumulated extensive experience in the treatment of rheumatic diseases.This article systematically reviewed the research progress of TCM in treating rheumatic diseases such as rheumatoid arthritis,systemic lupus erythematosus,Sj?gren's syndrome,ankylosing spondylitis,and osteoarthritis,as well as improving bone metabolism abnormalities closely related to rheumatic diseases,through regulating m6 A methylation.The aim is to provide novel insights into the treatment of rheumatic diseases with TCM and to offer theoretical support for the development of related functional drugs.
