Research progress of live-attenuated Salmonella-based carrier vaccine
10.16303/j.cnki.1005-4545.2025.09.28
- VernacularTitle:减毒活沙门菌作为口服疫苗载体的研究进展
- Author:
Xinyu LIU
1
;
Wenjin ZHANG
;
Yaolin CHEN
;
Xiaoping BIAN
;
Qing LIU
;
Qingke KONG
Author Information
1. 西南大学动物医学院,重庆 400715
- Publication Type:Journal Article
- Keywords:
live-attenuated Salmonella;
oral vaccine vector;
vaccine delivery
- From:
Chinese Journal of Veterinary Science
2025;45(9):2075-2085
- CountryChina
- Language:Chinese
-
Abstract:
Salmonella has demonstrated considerable potential as a vaccine vector,exhibiting robust immunogenicity,ease of oral administration,and cost-effective production.Live attenuated Salmo-nella carrying heterologous antigens can induce both localized mucosal immunity and systemic a-daptive immune responses in hosts after successfully reaching the intestinal tract via oral delivery.Recent advances such as permanent deletion of virulence genes,regulated-delayed attenuation and lysis systems,have initially achieved a balance between the safety and immunogenicity of these vaccine platforms.Nevertheless,practical applications of such vaccine vectors remain constrained by challenges related to gastrointestinal barrier obstruction,inefficient antigen delivery,and im-mune tolerance.With the rapid advancement of multidisciplinary technologies,these limitations are anticipated to be progressively addressed.This review presented a comprehensive summary and dis-cussion of the immune mechanisms,development strategies,current applications,advantages,and challenges associated with oral live attenuated Salmonella vaccine vectors.It also delineated the fu-ture direction of research and development,with a view to providing theoretical references for re-lated research.
