Deep stimulation lateral cerebellar nucleus enhances synaptic plasticity after medial prefrontal cortex injury in rat
10.16557/j.cnki.1000-7547.2025.05.009
- VernacularTitle:电刺激小脑外侧核促进内侧前额叶皮质损伤大鼠的突触可塑性
- Author:
Chengguo JIANG
1
;
Yong LIANG
1
;
Guangzhi HAO
1
;
Yushu DONG
1
Author Information
1. 中国人民解放军北部战区总医院神经外科,沈阳 110016
- Publication Type:Journal Article
- Keywords:
deep brain stimulation(DBS);
traumatic brain injury(TBI);
controlled cortical impact(CCI);
lateral cerebellar nucleus(LCN);
synaptic plasticity;
learning and memory;
rat
- From:
Chinese Journal of Neuroanatomy
2025;41(5):613-618
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of deep brain stimulation(DBS)of the lateral cerebellar nucleus(LCN)on synaptic plasticity in a traumatic brain injury(TBI)rat model of the medial prefrontal cortex(mPFC).Methods:A controllable mPFC injury rat model was prepared using a hydraulic impact method.Two weeks after inju-ry,stimulation electrodes were implanted into the left LCN.Electrical stimulation was initiated at the 4th week after injury and continued for 30 days.The learning and memory function of the rats was evaluated using the Morris water maze.RT-qPCR and Western blot were used to detect the mRNA and protein expressions of brain-derived neurotrophic factor(BDNF),postsynaptic density protein 95(PSD95),and growth-associated protein 43(GAP43)in the mPFC region.Results:The learning and memory function of the mPFC-injured rats significantly decreased.The expressions of BDNF,PSD95,and GAP43 in mPFC decreased.DBS treatment significantly enhanced the learning and memory ability of mPFC-injured rats,and simultaneously upregulated the expressions of BDNF,PSD95,and GAP43 in mPFC.Conclusion:LCN DBS is an effective method for treating cognitive impairment caused by TBI,and it may achieve this through activating the neural plasticity mechanism of the mPFC.
