Research progress of lymphocyte activation gene 3 and its role in infectious diseases
10.3969/j.issn.1000-484X.2025.04.040
- VernacularTitle:淋巴细胞活化基因3及其在感染性疾病中作用的研究进展
- Author:
Jie CHEN
1
;
Junchi XU
;
Rui QIANG
;
Xuanmiao LIU
;
Hui CHEN
;
Ping XU
Author Information
1. 苏州大学附属儿童医院检验科,苏州 215025;苏州大学苏州医学院,苏州 215131
- Publication Type:Journal Article
- Keywords:
Immune checkpoint;
LAG-3;
Infectious diseases;
Immune regulation
- From:
Chinese Journal of Immunology
2025;41(4):1016-1020
- CountryChina
- Language:Chinese
-
Abstract:
Infectious diseases refer to various diseases caused by pathogens invading human body.Lymphocyte activation gene 3(LAG-3)is a negative immune checkpoint molecule similar to CD4.Most studies have found that LAG-3 plays a regulatory role in occurrence and development of infectious diseases(acquired immunodeficiency disease,active pulmonary tuberculosis,chronic hepa-titis B,falciparum malaria)via inhibiting activation and function of CD4+T and CD8+T cells,and can serve as an effective potential immunotherapy target.This article will summarize researches of LAG-3 and its roles in infectious disease.
