Research advancements of immunomodulatory role of G-MDSCs in tumor and non-tumor diseases
10.3969/j.issn.1000-484X.2025.04.036
- VernacularTitle:G-MDSCs在肿瘤和非肿瘤疾病中免疫调控作用的研究进展
- Author:
Yan LIU
1
;
Fei ZHANG
;
Xiaowen ZHU
;
Zhuangzhuang ZHU-YANG
;
Chunpu ZOU
;
Zihang XU
Author Information
1. 上海中医药大学基础医学院上海健康辨识与评估重点实验室,上海 201203
- Publication Type:Journal Article
- Keywords:
G-MDSCs;
Tumor;
Non-tumor diseases;
Immunomodulation
- From:
Chinese Journal of Immunology
2025;41(4):990-997
- CountryChina
- Language:Chinese
-
Abstract:
Granulocytic myeloid-derived suppressor cells(G-MDSCs)are the principal subsets of myeloid-derived suppressor cells(MDSCs),which involved in development and progression of a variety of tumor and non-tumor diseases.G-MDSCs mediated disfunction of immune effector cells(such as T cells and NK cells)through producing Arg-1,ROS,iNOS,etc.is major cause of its immunosuppressive function.To date,a large number of studies have focused on tumor-promoting effects of G-MDSCs.However,their complex immunomodulatory functions,especially their positive effects in diseases such as autoimmune arthritis,are often overlooked.Besides,G-MDSCs share the same origin and phenotype with neutrophils,but their immune functions are heterogeneous.Therefore,precision of G-MDSCs targeted therapy will be largely improved if the two can be accurately distinguished,though this field is still under exploration.At present,there are abundant experimental studies on G-MDSCs at home and abroad,mainly in tumors,but there are no domestic reports on the immunomodulatory function of G-MDSCs in tumors and non-tumor diseases.Therefore,in this review,we summarizes the different roles played by G-MDSCs in tumor and non-tumor diseases,in order to reveal the important and complex functions of G-MDSCs in immune regulation.
