Correlation between chronic endometritis and peripheral blood immune indexes in patients with repeated implantation failure
10.3969/j.issn.1000-484X.2025.04.027
- VernacularTitle:反复种植失败患者慢性子宫内膜炎与外周血免疫指标的相关性研究
- Author:
Chun WU
1
;
Huibo RU
1
;
Jiuhua DONG
1
;
Xiu WANG
1
;
Suzhi ZHANG
1
;
Shusong WANG
1
;
Lirong DU
1
Author Information
1. 河北省生殖健康医院,河北省生殖医学重点实验室,石家庄 050071
- Publication Type:Journal Article
- Keywords:
Repeated implantation failure;
Chronic endometritis;
Hysteroscopy;
CD138;
Peripheral blood immune cell
- From:
Chinese Journal of Immunology
2025;41(4):938-942
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the prevalence of chronic endometritis(CE)in patients with repeated implantation failure(RIF),and the correlation between diagnostic indexes of CE and classification of peripheral blood immune cells.Methods:A total of 64 patients with RIF who visited Outpatient of Hebei Reproductive Health Hospital from January 2020 to December 2021 were retrospec-tively analyzed.General information of patients,results of hysteroscopy and endometrial immunohistochemistry in the mid luteal phase,the number and percentage of NK cells,Th1 cells,Th2 cells,Th17 cells and Treg cells in peripheral blood,and Th1/Th2,Th17/Treg were collected,and the pregnancy outcome of retransplantation was followed up.To evaluate the consistency of hysteroscopy and endometrial immunohistochemistry CD138 in diagnosis of CE in RIF patients,to analyze whether chronic inflammation of endome-trium was related to classification of peripheral blood immune cells,and to analyze the pregnancy outcome of patients with RIF diag-nosed with CE after retransplantation.Results:Prevalence of CE in RIF patients detected by hysteroscopy was 53.12%,which was sig-nificantly higher than that detected by endometrial immunohistochemistry CD138(25.00%,P<0.05).There was no significant differ-ence in the number and percentage of immune cells in peripheral blood between CE and non CE patients.After antibiotic treatment,the 12-week continuous pregnancy rate and live birth rate in the CD138 positive group were higher than those in negative group,with a statistically significant difference(P<0.05).Conclusion:The combination of hysteroscopy and endometrial CD138 immunohistochem-istry at the right time for RIF patients is beneficial to improve their pregnancy rate and pregnancy outcome.The infiltration of endome-trial plasma cells does not affect the classification of peripheral blood immune cells.
