Re-understanding of pulsed electric field ablation for atrial fibrillation
10.3969/j.issn.1004-8812.2025.11.008
- VernacularTitle:心房颤动脉冲电场消融的再认识
- Author:
Jian-gang XU
1
;
Kang LI
;
Jin-lin ZHANG
;
Zu-lu WANG
Author Information
1. 美敦力(上海)管理有限公司,上海 200126
- Publication Type:Journal Article
- Keywords:
Atrial fibrillation;
Pulsed field ablation;
Hemolysis;
Microbubbles
- From:
Chinese Journal of Interventional Cardiology
2025;33(11):652-656
- CountryChina
- Language:Chinese
-
Abstract:
Catheter-based pulsed field ablation(PFA)for atrial fibrillation ablation has been widely adopted worldwide in recent years,accumulating substantial evidence for its efficacy and safety.However,several adverse events associated with this technology have also been observed,such as PFA-related coronary artery spasm,hemolysis,acute renal injury,and symptomatic or asymptomatic cerebrovascular events.This review summarizes the latest basic and clinical research advances in PFA over the past two years,focusing on biophysical aspects including the field intensity of PFA,the thermal effects of PFA,contact force,and the number of applications.We discuss whether PFA demonstrates tissue selectivity,the mechanisms of hemolysis and microbubble formation,as well as the lesion morphology and impact factors to lesion depth.This review aims to provide clinicians with a more in-depth understanding of PFA technology and biphasic to optimize clinical application.
