New progress in pathogenic effect of pyroptosis in rheumatoid arthritis
- VernacularTitle:细胞焦亡在类风湿关节炎中致病作用的新进展
- Author:
Jing MAO
1
;
Min TAN
1
;
Jiayao HAO
1
;
Rui ZHANG
1
;
Wenhua LI
1
;
Xianmeng ZHANG
1
;
Haili SHEN
1
Author Information
- Publication Type:Journal Article
- Keywords: Pyroptosis; Rheumatoid arthritis; Pathogenic effect
- From: Chinese Journal of Immunology 2025;41(4):1021-1024,后插1
- CountryChina
- Language:Chinese
- Abstract: Pyroptosis is a novel,inflammatory programmed cell death mediated by gasdermins(GSDMs),which characterized by the formation of membrane pores and the release of pro-inflammatory cytokines.Rheumatoid arthritis(RA)is a chronic,inflamma-tory autoimmune disease characterized by persistent synovitis in multiple joints,progressive destruction of bone and cartilage,and eventually leading to joint deformity and disability.Recently,it has been shown that pyroptosis plays an important role in development of RA.This review summarizes the molecular mechanism of pyroptosis,its pathogenic role and therapeutic strategies in RA,aiming of providing new insights for the mechanism research and new drug development of RA.
