Advances of DNA methylation in primary immune thrombocytopenia
10.3969/j.issn.1000-484X.2025.04.039
- VernacularTitle:DNA甲基化在原发免疫性血小板减少症中的研究进展
- Author:
Weiwei MIAO
1
;
Xiangdong YANG
;
Lijun FANG
;
Zheng HAO
;
Jiangshui GUO
;
Kangkang BAI
Author Information
1. 天津中医药大学第一附属医院,国家中医针灸临床医学研究中心,天津 300381
- Publication Type:Journal Article
- Keywords:
Primary immune thrombocytopenia;
DNA methylation;
Autoimmunity;
Polymorphism
- From:
Chinese Journal of Immunology
2025;41(4):1010-1015
- CountryChina
- Language:Chinese
-
Abstract:
Primary immune thrombocytopenia(ITP)is an acquired autoimmune hemorrhagic disease characterized by reduced isolated peripheral blood platelet counts for which pathogenesis and etiology are not well defined.Present diagnosis of ITP is to be excluding other diseases,whose pathogenesis generally involves multiple aspects of immunology,biology,epigenetics and environ-mental factors.Recognition of epigenetic alterations in dysregulation of immune tolerance and autoimmune diseases has been deepened in recent years with progress by molecular biology.DNA methylation,an important epigenetic modification,has been shown to play a role in pathogenesis of ITP.Abnormal DNA methylation leads to cellular abnormalities in proliferation,differentiation,apoptosis and immune response in body,induces immune intolerance to autologous platelet antigens in patients,resulting in abnormal activation of immune cells which makes excessive platelet destruction or insufficient platelet production.Therefore,this article reviews latest research progress of DNA methylation genes in ITP to provide a reference for further recovery of immune tolerance of patients.
