Application of serum IgG4 detection in diagnosis,treatment and prognosis of IgG4-RD
10.3969/j.issn.1000-484X.2025.04.029
- VernacularTitle:血清IgG4检测在IgG4-RD诊治和转归中的应用研究
- Author:
Yanyan YANG
1
;
Sainan LI
;
Yuxin XIA
;
Yuzhang JIANG
Author Information
1. 江苏泗洪分金亭医院检验科,泗洪 223900
- Publication Type:Journal Article
- Keywords:
IgG-related diseases(IgG4-RD);
Immunoglobulin G subtype;
Serum
- From:
Chinese Journal of Immunology
2025;41(4):948-953
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the value of serum IgG4 detection in diagnosis,treatment,evaluation and outcome of IgG4-associated diseases(IgG4-RD).Methods:By integrating the clinical data of patients,retrospectively and systematically analyze the results of common laboratory examinations,imaging examinations,pathological examinations,etc.26 patients who were diagnosed with IgG4-RD in Huaian First Hospital Affiliated to Nanjing Medical University from March 2013 to October 2023.Results:The median age of onset was 65(31～90)years old,and the male to female ratio was 3.33∶1.The first three symptoms were abdominal discomfort,skin scleral yellow stain and fever.Patients mainly involved multiple organs,the most commonly involved organs were lung,pancreas,liver,kidney,bile duct.Compared with the control group,NLR,PLR,ESR,CRP,TBIL,DBIL,ALT,AST,GGT,IgG,IgA and IgM were all abnormally elevated in the first hematological,biochemical and immune tests of the patients,the difference was statisti-cally significant,while C3 and C4 were all decreased,but there was no statistical difference.The first IgG4 level of IgG4-RD patients was correlated with the length of hospitalization,the length of return visit,and the dynamic changes of IgG4 level after return visit.Conclusion:Serum IgG4 detection plays an important role in the diagnosis and treatment of IgG4-RD.In patients with abnormally high level of IgG4,those who are sensitive to high-dose glucocorticoid therapy have a faster decline in IgG4 levels and a longer duration of symptom remission.
