Regeneration and repair of oral alveolar bone defects

Xinyue LIU; Chunnian LI; Yizhuo LI; Shifang XU

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Regeneration and repair of oral alveolar bone defects

VernacularTitle:口腔牙槽骨缺损的再生修复
Author: Xinyue LIU ¹ ; Chunnian LI ¹ ; Yizhuo LI ¹ ; Shifang XU ¹
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1. 河北医科大学口腔医学院·口腔医院(河北省口腔医学重点实验室),河北省石家庄市 050017
Publication Type:Journal Article
Keywords: alveolar bone defect; bone regeneration and repair; nano-scaffold materials; hydrogels; Western medicine; Chinese medicine; growth factors; stem cells; engineered tissue construction
From: Chinese Journal of Tissue Engineering Research 2026;30(5):1247-1259
CountryChina
Language:Chinese
Abstract: BACKGROUND:Developing a material that promotes alveolar bone regeneration and has good properties is of great significance for the treatment of alveolar bone defects.OBJECTIVE:To summarize the research on alveolar bone defect regeneration and repair in the past 5 years,classify and introduce new materials and drugs,so as to grasp the latest progress in related fields.METHODS:"Alveolar bone,alveolar bone defect,alveolar bone regeneration,mechanism,biomaterials,nanoscaffolds,hydrogels,medications,anti-inflammatory drugs,simvastatin,metformin,traditional Chinese medicine,growth factor,stem cell"were used as search terms in Chinese and English for literature retrieval in CNKI and PubMed,respectively.A total of 117 articles were finally obtained for review and analysis.RESULTS AND CONCLUSION:The application of biomaterials provides a scaffold structure for alveolar bone regeneration and can also be used as a bone substitute to repair bone defects.Topical and systemic applications of Western and Chinese medicines can control inflammation and promote bone regeneration.Materials loaded with various growth factors have the effect of osteogenesis and can promote the repair of alveolar bone defects.In stem cell tissue engineering,the seed cells are osteogenic and fibrogenic,which can differentiate into osteoblasts to generate new bone.In recent years,research has been keen on the combination of the above to develop new,biocompatible,and slow-release drugs or materials to promote the regeneration and repair of alveolar bone defects.