Difference of clinical characteristics between complete Kawasaki disease and incomplete Kawasaki disease and analysis of intervention effect of gamma globulin combined with aspirin
10.3969/j.issn.1000-484X.2025.04.032
- VernacularTitle:完全川崎病和不完全川崎病的临床特点差异及丙种球蛋白联合阿司匹林的干预效果分析
- Author:
Xiaoshi SHANG
1
;
Jianye LI
1
Author Information
1. 平顶山市妇幼保健院,平顶山 467000
- Publication Type:Journal Article
- Keywords:
Kawasaki disease;
Gamma globulin;
Aspirin;
Immune function
- From:
Chinese Journal of Immunology
2025;41(4):967-971
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the difference of clinical characteristics between complete Kawasaki disease and incom-plete Kawasaki disease and the intervention effect of gamma globulin combined with aspirin.Methods:Using prospective studies,N=Z2×σ2/d2 was used to calculate the sample size.A total of 120 patients with Kawasaki disease diagnosed and treated in Pingdingshan Maternal and Child Health Hospital from November 2017 to October 2022 were selected as research objects,including 54 patients with complete Kawasaki disease and 66 patients with incomplete Kawasaki disease.All patients were treated with gamma globulin combined with aspirin,clinical features and laboratory indexes of patients with complete Kawasaki disease and those with incomplete Kawasaki disease were compared,and the differences in clinical symptom improvement,immune function,inflammatory response indexes and complications before and after treatment of patients with complete Kawasaki disease and incomplete Kawasaki disease were studied.Results:There was no statistical significance in lip changes and fever between complete Kawasaki disease patients and incomplete Kawasaki disease patients(P>0.05).Perianal molting,hand and foot swelling and peeling,cervical lymph node enlarge-ment,rash and conjunctival congestion in complete Kawasaki disease group were significantly higher than those in incomplete Kawasaki disease patients(P<0.05);there was no statistical significance in leukocytes,platelets,C-reactive protein(CRP),erythrocyte depo-sition,hemoglobin and aspartic transferase in patients with complete Kawasaki disease and incomplete Kawasaki disease(P>0.05);time of fever reduction,hand and foot swelling,neck lymph node dissipation and conjunctival congestion in complete Kawasaki dis-ease patients were significantly shorter than those in incomplete Kawasaki disease group(P<0.05).After treatment,CD4+CD25+Treg and Th17 in two groups were significantly decreased,and CD4+CD25+Treg and Th17 in complete Kawasaki disease were significantly lower than those in incomplete Kawasaki disease(P<0.05).CRP,IL-6 and TNF-α in two groups were significantly decreased,and the CRP,IL-6 and TNF-α in complete Kawasaki disease were significantly lower than those in incomplete Kawasaki disease(P<0.05).Diameter reduction condition of left main coronary artery,right trunk coronary artery,left anterior descending coronary artery and left circumflex coronary artery in complete Kawasaki disease group were significantly higher than those in incomplete Kawasaki disease group(P<0.05).Conclusion:Clinical characteristics of complete Kawasaki disease and incomplete Kawasaki disease are mainly dif-ferent in clinical manifestations,blood indexes and clinical improvement.In the treatment of complete Kawasaki disease,gamma glob-ulin combined with aspirin can significantly improve the inflammatory response and immune function of patients,and the effect is good.
