Intra-articular injections for the treatment of osteoarthritis of the temporomandibular joint:different drugs with multiple combined treatment options
- VernacularTitle:关节腔注射治疗颞下颌关节骨关节炎:不同药物与多种联合治疗方案
- Author:
Yangyang BU
1
;
Xinli NING
;
Chen ZHAO
Author Information
- Publication Type:Journal Article
- Keywords: osteoarthritis of the temporomandibular joint; osteoarthritis; intra-articular injection; drug therapy; combination therapy; engineered tissue construction
- From: Chinese Journal of Tissue Engineering Research 2026;30(5):1215-1224
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Intra-articular injection therapy is a relatively safe and effective treatment that can effectively relieve clinical signs and symptoms of patients with osteoarthritis of the temporomandibular joint.OBJECTIVE:To summarize new developments in the types of intra-articular injectable drugs and multiple combined treatment options for patients with osteoarthritis of the temporomandibular joint.METHODS:We searched relevant articles included in CNKI and PubMed databases with the keywords of"temporomandibular joint osteoarthritis,steroid hormone,nonsteroidal anti-inflammatory drugs,hyaluronic acid,ozone,chitosan,platelet-rich plasma,stem cell,exosome,intra-articular injection,arthrocentesis,drug therapy,therapy"in Chinese and English,respectively.A total of 67 articles were finally included for review.RESULTS AND CONCLUSION:(1)The application of intra-articular injection therapy in osteoarthritis of the temporomandibular joint is promising.There is a wide range of injectable drugs,including glucocorticoids,hyaluronic acid,chitosan,and platelet-rich plasma.Although the results of the existing studies show good efficacy,large-scale randomized controlled trials are still needed to further verify its safety and efficacy.(2)Different combinations of drugs injected into the joint cavity have shown better efficacy in osteoarthritis of the temporomandibular joint,and future studies should focus on the optimal combinations of different drugs as well as combinations of drugs with other therapeutic options,to provide a more effective treatment option for patients with osteoarthritis of the temporomandibular joint.
