Research progress in the treatment of pancreatic neuroendocrine neoplasms with liver metastases
10.7659/j.issn.1005-6947.230441
- VernacularTitle:胰腺神经内分泌肿瘤合并肝转移的治疗研究进展
- Author:
Shaolong LU
1
;
Xiaobo WANG
1
;
Yejian WAN
1
;
Jie LIN
1
;
Jie CHEN
1
Author Information
1. 广西医科大学附属肿瘤医院 肝胆外科,广西 南宁 530021
- Publication Type:Journal Article
- Keywords:
Pancreatic Neoplasms;
Neuroendocrine Neoplasms;
Neoplasm Metastasis;
Liver;
Review
- From:
Chinese Journal of General Surgery
2025;34(3):555-562
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic neuroendocrine neoplasms(pNENs)are rare and highly heterogeneous pancreatic tumors with insidious clinical manifestations.They have a high propensity for distant metastasis,with liver metastases being the most common,significantly impacting patient prognosis.Despite extensive research on treating pNEN with liver metastases in recent years,many controversies and gaps remain.With the advancement of multidisciplinary treatment approaches,therapeutic strategies for pNEN liver metastases have been continuously refined,encompassing surgical resection,local therapies(such as radiofrequency ablation and transarterial interventions),and systemic treatments(including chemotherapy,targeted therapy,immunotherapy,radionuclide therapy,and endocrine therapy).Combination therapy has become an emerging trend.Radical surgery remains the preferred option for resectable cases,while for inoperable or treatment-intolerant patients,a rational combination of local and systemic therapies can improve survival outcomes.Additionally,endocrine therapy is crucial in symptom relief and quality-of-life improvement for patients with functional pNEN.Multidisciplinary collaboration in formulating individualized treatment plans can significantly enhance patient prognosis.This review summarizes recent advancements in treating pNEN liver metastases,providing a reference for clinical decision-making.
