Roles of Nrf2 in inflammatory bowel disease-associated inflammatory-cancer transition
10.13431/j.cnki.immunol.j.20250007
- VernacularTitle:Nrf2在炎症性肠病癌化中的作用
- Author:
Nan WU
1
;
Yisen HU
;
Haiqiang WANG
Author Information
1. 150040 哈尔滨,黑龙江中医药大学研究生院
- Publication Type:Journal Article
- Keywords:
Nrf2;
Inflammation-cancer transformation;
Inflammatory bowel disease;
Oxidative stress
- From:
Immunological Journal
2025;41(1):52-58
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease(IBD)is a chronic nonspecific inflammatory disease of the intestines,mainly including Crohn's disease(CD)and ulcerative colitis(UC).More than 20％of IBD patients progress to colitis-associated colorectal cancer(CAC)through the inflammation-cancer sequence within 30 years of disease onset.Nuclear transcription factor E2-related factor 2(Nrf2)is a transcription factor closely related to IBD and CAC,which not only affects inflammation but also plays a significant role in regulating the"Inflammation-cancer transformation".In this paper,we review the studies on the mechanism of Nrf2 in the"Inflammation-cancer transformation",focusing on the mechanism and dual roles of Nrf2 in oxidative stress,inflammatory factors,immune response,metabolic reprogramming and gene expression,with an aim of providing a reference for further understanding the potential value of its intervention in the human tumor process.
