A Case Report of Severe Bradycardia Associated With Nirmatrelvir-ritonavir Drug-drug Interactions
10.1097/CD9.0000000000000150
- VernacularTitle:A Case Report of Severe Bradycardia Associated With Nirmatrelvir-ritonavir Drug-drug Interactions
- Author:
Zhiqing FU
1
;
Yan GUO
1
;
Shuai LI
1
;
Yang SHI
1
Author Information
1. Department of Cardiology, the Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese People’s Liberation Army General Hospital, Beijing 100853, China
- Publication Type:Journal Article
- Keywords:
Bradycardia;
Nirmatrelvir-ritonavir;
Drug interactions;
Elderly;
Case report
- From:
Cardiology Discovery
2025;05(1):91-93
- CountryChina
- Language:English
-
Abstract:
With the increasing use of nirmatrelvir-ritonavir in older COVID-19 patients, adverse drug reactions due to drug-drug interactions have become more frequent. This report describes a patient who experienced severe bradycardia and hypotension following the concurrent use of heart rate-control medications and nirmatrelvir-ritonavir during an active COVID-19 infection. This suggests that clinicians should be cautious when dealing with nirmatrelvir-ritonavir and try their best to avoid serious adverse reactions.
