The influence of autoimmune diseases on early spontaneous abortion
10.13431/j.cnki.immunol.j.20250006
- VernacularTitle:多种自身免疫性疾病对早期自然流产的影响
- Author:
Ganlu PENG
1
;
Shuang DAI
1
;
Man LU
1
;
Guosheng LI
1
;
Quan ZHOU
1
;
Aihua CHEN
1
Author Information
1. 443000 宜昌,三峡大学第一临床医学院
- Publication Type:Journal Article
- Keywords:
Autoimmune disease;
Early spontaneous abortion;
Thyroid autoimmunity;
Systemic lupus erythematosus;
Antiphospholipid syndrome
- From:
Immunological Journal
2025;41(1):44-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate of the effect of autoimmune diseases(AIDs)on early spontaneous abortion(ESA).Methods Several databases such as Ovid and Web of Science were searched from January 2000 to May 2024 for retrospective analysis.Furthermore,subgroup analysis was conducted in terms of AIDs,continent and assisted reproduction.Results Total of 73 eligible studies were included in this study.There was a statistically significant difference in the risk of ESA between the population with AIDs and the population with normal pregnancy(OR=1.832,95％CI:1.619-2.073).When subgroup studies of AIDs were performed,the increased risk of ESA in patients with some AIDs was statistically significant:e.g.,thyroid autoimmunity,antiphospholipid syndrome,systemic lupus erythematosus,desiccation syndrome,antinuclear antibody positivity and rheumatoid arthritis.While the impact of some AIDs on ESA was still uncertain,e.g.inflammatory bowel disease,ulcerative colitis,Crohn's disease,autoimmune skin diseases,neuromyelitis optica spectrum disorders.In addition,patients with antiphospholipid syndrome who had underwent assisted reproductive technologies were at higher risk of ESA.Furthermore,compared to other continents,there is a difference in the risk of ESA in patients with AIDs in Africa.Conclusion AIDs are associated with the risk of ESA.
