Therapeutic effect of levocarnitine combined with Shenmai injection on heart failure caused by ischemic cardiomyopathy:a meta-analysis
10.3969/j.issn.1008-0074.2025.02.16
- VernacularTitle:左卡尼汀联合参麦注射液治疗缺血性心肌病心力衰竭效果的Meta分析
- Author:
Qiang HUANG
1
;
Shu-dan ZHANG
Author Information
1. 鞍山市中心医院药剂科,辽宁鞍山 114000
- Publication Type:Journal Article
- Keywords:
Heart failure;
L-carnitine;
Shenmai injection;
Meta-analysis
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2025;34(2):216-221
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To review systematically the curative effect and safety of levocarnitine combined with Shenmai injection in the treatment of heart failure caused by ischemic cardiomyopathy.Methods:We searched the databases of PubMcd,Cochrane Library,EMbase,CBM,CNKI,WanFang and VIP for randomized controlled trials(RCTs)comparing the effect upon heart failure caused by ischemic cardiomyopathy between levocarnitine combined with Shenmai injection versus standard treatment from the establishment to June 12th,2023.The pooled odds ratio(OR)or mean difference(MD)with 95％confidence interval(CI)were calculated with a Meta-analysis using the Rev-Man 5.4 software.Results:21 eligible literatures were included,involving 2055 patients[mean age(63.86±9.90)years,males 61.27％].Pooled analysis showed that levocarnitine combined with Shenmai injection significantly im-proved the total effective rate(OR=5.04,95％CI 3.78～6.71,P＜0.001),left ventricular ejection fraction(MD=6.10,95％CI 5.18～7.02,P＜0.001),stroke volume(MD=10.64,95％CI 7.42～13.85,P＜0.001),cardiac output(MD=0.85,95％CI 0.74～0.97,P＜0.001),left ventricular fractional shortening(MD=5.27,95％CI 4.16～6.39,P＜0.001),and significantly reduced left ventricular end-diastolic diameter(MD=-5.64,95％CI-7.31～-3.98,P＜0.001)and left ventricular end-systolic diameter(MD=-5.08,95％CI-6.08～-4.09,P＜0.001)than standard treatment.There were no significant differences in the adverse reaction rate be-tween groups(P=0.220).Conclusion:Current research evidence suggests that levocarnitine combined with Shen-mai injection had better efficacy on the heart failure caused by ischemic cardiomyopathy,with good safety.
