Advances in the Role of FAM111B Gene in Immune Microenvironment of Ovarian Cancer
10.3870/j.issn.1672-0741.24.07.024
- VernacularTitle:FAM111B基因在卵巢癌肿瘤免疫微环境中作用的研究进展
- Author:
Wanying LI
1
;
Fang WEI
1
;
Lihong ZHANG
1
Author Information
1. 华中科技大学同济医学院附属同济医院肿瘤科,武汉 430030
- Publication Type:Journal Article
- Keywords:
ovarian cancer;
FAM111B;
tumor immune microenvironment;
PD-L1;
immunotherapy
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2025;54(2):261-266
- CountryChina
- Language:Chinese
-
Abstract:
Ovarian cancer(OC)is a prevalent malignant gynecological tumor with a high mortality rate.The tumor immune microenvironment,consisting of immune components within the tumor microenvironment,plays a significant role in tumor devel-opment and metastasis.OC is typically categorized as a"cold tumor"due to its immunosuppressive microenvironment,resulting in limited efficacy of immunotherapy for this disease.Specifically,the expression of family with sequence similarity 111 member B(FAM111B)protein has been found to be correlated with the immune microenvironment of various tumors,including its associ-ation with the expression of programmed death ligand-1(PD-L1)in ovarian cancer tissues.This review provides an overview of recent research developments concerning the impact of the FAM111B gene on the immune microenvironment of ovarian cancer.
