Irreversible Electroporation Ablation for Atrial Fibrillation: Status and Challenges
10.1097/CD9.0000000000000045
- VernacularTitle:Irreversible Electroporation Ablation for Atrial Fibrillation: Status and Challenges
- Author:
Fei XIE
1
;
Yonggang CHEN
;
Xinhua CHEN
;
Zhihong ZHAO
Author Information
1. Key Laboratory of Pulsed Power Translational Medicine of Zhejiang Province, Hangzhou, Zhejiang 310003, China
- Publication Type:Journal Article
- Keywords:
Atrial fibrillation;
Irreversible electroporation;
Ablation
- From:
Cardiology Discovery
2022;02(1):41-50
- CountryChina
- Language:English
-
Abstract:
Pulsed electric field (PEF) is a novel energy source by which high-voltage electric pulses are used to create irreversible electroporation. PEF is non-thermal and highly tissue-dependent in which specific targeting of the atrial myocardium is achieved and sparing of adjacent tissues is feasible, theoretically increasing the safety of the procedure, which could potentially break the trade-off between effective lesions and collateral damage and substantially improve risk-benefit ratios in atrial fibrillation (AF) ablation. Although recently published trials have shown a clear effect of AF ablation, large-scale clinical trials are lacking. Current clinical evidence has demonstrated significant efficacy in achieving durable pulmonary vein isolation without ablation-related adverse events. However, their putative benefits regarding efficacy, efficiency, and safety remain to be proven in randomized controlled trials.
