Research on the inhibition of glycyrrhizic polysaccharide on the growth and migration of salivary adenoid cystic carcinoma cells
10.13591/j.cnki.kqyx.2025.11.005
- VernacularTitle:甘草多糖抑制唾液腺腺样囊性癌生长和迁移能力的研究
- Author:
Tangjun LIU
1
;
Tianyu SHAN
;
Xinwei WANG
;
Dandan SUN
;
Jiajia LIU
;
Yunxia LIU
Author Information
1. 山东第二医科大学口腔医学院,山东潍坊(261053)
- Publication Type:Journal Article
- Keywords:
salivary adenoid cystic carcinoma;
glycyrrhizic polysaccharide;
migration
- From:
STOMATOLOGY
2025;45(11):826-831
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of glycyrrhizic polysaccharide(GP)on the biological activity of salivary adenoid cystic carcinoma tumor cells and its mechanisms of anti-tumor action.Methods GP was prepared,and human adenoid cystic carcinoma high-metastatic cell line SACC-LM and low-metastatic cell line SACC-83 were used as target cells.Different concentrations of GP were used for intervention.The cell counting kit-8(CCK-8)assay was employed to detect cell proliferation and apoptosis.Reverse transcrip-tion polymerase chain reaction(RT-PCR)and Western blot experiments were conducted to detect the expression of genes and proteins related to tumor invasion and metastasis.The scratch assay was used to observe the effect of GP on the migration ability of SACC cells.In vivo experiments were conducted to verify the inhibitory effect of GP on tumor cells.Results Glycyrrhiza polysaccharides signifi-cantly inhibited the proliferation and migration of the highly metastatic human adenoid cystic carcinoma cell line SACC-LM by regulating the expression of epithelial-mesenchymal transition(EMT)-related markers.In vivo experiments showed that glycyrrhiza poly-saccharides had no significant hepatotoxicity,could significantly reduce the volume and weight of tumors,and inhibit the growth rate of tumors in nude mice.Conclusion GP has a certain inhibitory effect on the growth and migration ability of SACC.
