Correlation between Sleep Status and Cognitive Function in Middle-aged and Elderly People in China and the Mediating Effect of Depres-sion
10.11969/j.issn.1673-548X.2025.02.024
- VernacularTitle:我国中老年人睡眠状况与认知功能的关联及抑郁的中介效应
- Author:
Yang XIANG
1
;
Zhenkun LI
;
Naipeng LIU
Author Information
1. 230001 合肥,中国科学技术大学附属第一医院(安徽省立医院)总院病案统计室
- Publication Type:Journal Article
- Keywords:
Cognitive function;
Sleep status;
Depression;
Mediating effect
- From:
Journal of Medical Research
2025;54(2):152-158
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the relationship between sleep status and cognitive function in middle-aged and elderly peo-ple in China,as well as the mediating effect of depression.Methods Selecting middle-aged and elderly people aged 45 years and above from the 2020 China Health and Retirement Longitudinal Survey(CDHARLS),K-means clustering method was used to divide cognitive function into high score group and low score group.Logistic regression analysis was used to analyze the influencing factors of cognitive function,and a restricted cubic spline model was used to explore the dose-response relationship between sleep and cognitive function.A structural equation model was constructed to analyze the mediating effect of depression between sleep status and cognitive function.Results Among 7964 middle-aged and elderly people,the cognitive function score was 13.49±2.99 points,the depression detection rate was 30.8％.After controlling for other confounding factors,the probability of cognitive decline in middle-aged and elderly people with a nighttime sleep duration of＞8hours was 1.4 times that of a nighttime sleep duration of 6-8hours,and the probability of cognitive decline in middle-aged and elderly people with a nap duration of 0-30minutes and≥90minutes was 1.20 times and 1.39 times that of a nap du-ration of 30-60minutes.The probability of cognitive decline in middle-aged and elderly people with depression was 1.52 times that of the non-depression group.The restricted cubic spline model showed that there was a U-shaped and J-shaped correlation between nighttime and afternoon sleep duration and the risk of cognitive decline.The results of the structural equation model showed that sleep sta-tus had a direct effect on cognitive function(β=-0.278,95％CI:-0.376--0.186),while depression has an indirect effect be-tween sleep status and cognitive function(β=0.152,95％CI:0.111-0.201).Conclusion The sleep status,depression,and cogni-tive function of middle-aged and elderly people in China are closely related,and depression mediates the relationship between sleep sta-tus and cognitive decline a certain extent.
