Short and longterm outcomes after laparoscopic and open radical ante-grade modular pancreatosplenectomy:a propensity score matched study
10.3969/j.issn.1009-9905.2025.11.001
- VernacularTitle:腹腔镜或开腹根治性顺行模块化胰脾切除术治疗远端胰腺癌的近远期疗效对比
- Author:
Pan-pan FENG
1
;
Xin-rui LIU
;
Jing-yi HE
Author Information
1. 山东第一医科大学附属省立医院 血液科(山东 济南 250021)
- Publication Type:Journal Article
- Keywords:
Radical antegrade modular pancreatosplenectomy;
Pancreatic cancer;
Propensity score matching
- From:
Chinese Journal of Current Advances in General Surgery
2025;28(11):841-846
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the safety,short-term and long-term efficacy of laparoscopic radical antero-grade modular pancreatic-splenic resection(L-RAMPS)and open radical anterograde modular pancreatic-splenic resec-tion(RAMPS)in the treatment of distal pancreatic cancer,providing clinical evidence for the development of minimally in-vasive surgery for distal pancreatic cancer.Methods:Clinical and follow-up data of patients with distal pancreatic can-cer who underwent surgical treatment at Department of Liver Transplantation and Hepatobiliary Surgery,Shandong Pro-vincial Hospital Affiliated to Shandong First Medical University,between January 2019 and October 2021 were retro-spectively collected.Patients were divided into a L-RAMPS group(n=70)and a RAMPS group(n=36)based on the sur-gical approach.Propensity score matching(PSM)was applied in a 1:1 ratio to compare short-term and long-term out-comes between the two groups.Results:After PSM,L-RAMPS group has the advantage of less estimated blood loss(50 mL vs 180 mL,P=0.002)and a shorter postoperative length of stay(6 d vs 8 d,P<0.001).No statistically significant differences were observed in long-term survival and postoperative complication rates between these two groups(P>0.05).Univariate and multivariate analyses identified preoperative serum CA19-9 levels,peritumoral tissue infiltration,perineural invasion,and lymph node metastasis as independent risk factors for early postoperative tumor recurrence.Conclusion:This study has demonstrated that L-RAMPS for patients with distal pancreatic cancer has the advantage of less estimated blood loss and a shorter postoperative length of stay.The short-term and long-term efficacy of L-RAMPS is comparable to that of RAMPS.L-RAMPS is a safe and effective surgical method for patients with distal pan-creatic cancer.
