Scientific Connotations of the Traditional Chinese Medicine Theory of"Epilepsy Caused by Frailty"Based on Mendelian Randomization
10.11969/j.issn.1673-548X.2025.02.016
- VernacularTitle:基于孟德尔随机化方法探析中医"因虚致痫"理论的科学内涵
- Author:
Junlong CHEN
1
;
Jialin LIU
;
Xiangchun ZHENG
Author Information
1. 100078 北京中医药大学东方医院脑病三科
- Publication Type:Journal Article
- Keywords:
Epilepsy;
Frailty;
Mendelian randomization;
"Epilepsy caused by frailty"theory;
Traditional Chinese medicine
- From:
Journal of Medical Research
2025;54(2):96-102
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the causal relationship between frailty and epilepsy based on the traditional Chinese medicine(TCM)theory of"epilepsy caused by frailty"utilizing a two-sample Mendelian randomization approach,to enrich the modern connota-tion of the"epilepsy caused by frailty"theory and provide a theoretical basis for treating epilepsy from a frailty perspective in TCM.Methods Data on frailty and epilepsy were extracted from publicly available genome-wide association study summary datasets.Single nucleotide polymorphism(SNP)were selected as instrumental variable under the conditions of P＜5 x 10-8,a linkage disequilibrium co-efficient of 0.001,and a linkage disequilibrium region width of 10000kb.Mendelian randomization analysis was performed using five methods:MR-Egger regression,weighted median,inverse variance weighting,simple mode and weighted mode,with inverse variance weighting as the primary analysis method.The causal relationship between frailty and epilepsy was interpreted using OR and 95％CI.Pleiotropy was assessed using the MR-Egger intercept and MR-PRESSO analysis methods,while heterogeneity was analyzed using MR-Egger Cochran's Q test,and sensitivity analysis was conducted using the leave-one-out method.Results The results of inverse variance weighting and weighted median analysis indicated that there was a positive causal relationship between frailty and epilepsy.This result passed pleiotropy tests,confirming its robustness.Conclusion Frailty is associated with an increased risk of epilepsy,which is consistent with the TCM understanding of"epilepsy caused by frailty".It is suggested that in clinical treatment,besides conventional ap-proaches such as resolving phlegm,eliminating blood stasis,calming wind,and opening orifices,there should be a greater emphasis on tonifying frailty and nurturing the body's vital energy.
