Progress in role and mechanism of perilipin 2 in nonalcoholic fatty liver disease
10.3969/j.issn.1000-4718.2025.00.003
- VernacularTitle:脂滴包被蛋白2在非酒精性脂肪性肝病中作用及机制的研究进展
- Author:
Zhuoya XU
1
;
Hong QIN
1
;
Wenya ZHENG
1
Author Information
1. 中南大学湘雅公共卫生学院营养与食品卫生学教研室,湖南 长沙 410006
- Publication Type:Journal Article
- Keywords:
perilipin 2;
nonalcoholic fatty liver disease;
lipid metabolism;
oxidative stress;
inflammation
- From:
Chinese Journal of Pathophysiology
2025;41(2):376-381
- CountryChina
- Language:Chinese
-
Abstract:
Perilipin 2(PLIN2)is located on the surface of lipid droplets,acting as an important marker pro-tein of liver lipid droplets.Several studies have shown the crucial role of PLIN2 in regulating liver lipid metabolism by modulating the formation and stability of lipid droplets.Additionally,it is also directly or indirectly involved in many physio-logical and disease processes related to nonalcoholic fatty liver disease(NAFLD),thereby playing an important role in the development of NAFLD.This paper reviews the distribution,structure,function and role of PLIN2 in NAFLD to provide insights into the development of PLIN2-targeted drugs for the prevention and treatment of NAFLD.
