Serum levels of TBARS and 8-OHdG in patients with depression and their relationship with disease severity and cognitive function
10.12007/j.issn.0258-4646.2025.11.007
- VernacularTitle:抑郁症患者血清TBARS和8-OHdG水平及其与病情严重程度和认知功能的关系
- Author:
Pin LÜ
1
;
Yue TAN
1
Author Information
1. 江西省精神病院心理科,南昌 330001
- Publication Type:Journal Article
- Keywords:
depression;
disease severity;
cognitive function;
thiobarbituric acid reactive substance;
8-hydroxydeoxyguanosine
- From:
Journal of China Medical University
2025;54(11):1000-1004
- CountryChina
- Language:Chinese
-
Abstract:
Objective To measure the changes in serum thiobarbituric acid reactive substance(TBARS)and 8-hydroxydeoxyguanosine(8-OHdG)levels in patients with depression and explore their relationship with disease severity and cognitive function.Methods The clinical data of 150 patients with depression were collected.The patients were assigned to the mild depression group(n=53),moderate depression group(n=62),and severe depression group(n=35)complying with the HAMD-24 score,and further assigned to the cognitive normal group(n=83)and cognitive dysfunction group(n=67)complying with the MoCA score.The control group included 75 healthy volunteers.The serum TBARS and 8-OHdG levels were detected using the enzyme-linked immunosorbent assay.Spearman's correlation analysis was used to investigate the correlation of serum TBARS and 8-OHdG levels with depression severity and MoCA scores in patients with depression.In addition,the diagnostic value of serum TBARS and 8-OHdG levels for cognitive dysfunction in patients with depression was evaluated using a receiver operating characteristic curve.Results The serum TBARS and 8-OHdG levels were higher in the patients with depression(P＜0.05)than in the healthy volumteers.The serum TBARS and 8-OHdG levels were higher in the severe depression group than in the mild and moderate depression groups(P＜0.05),and higher in the moderate depression group than in the mild depres-sion group(P＜0.05).The serum TBARS and 8-OHdG levels positively correlated with depression severity(r=0.615,r=0.709,both P＜0.001).The serum TBARS and 8-OHdG levels in the cognitive dysfunction group were higher than those in the cognitive normal group(P＜0.05)and were negatively correlated with the MoCA score(r=-0.343,r=-0.430,both P＜0.001).Moreover,the area under the curve of the combination of serum TBARS and 8-OHdG levels for diagnosing cognitive dysfunction in patients with depression was 0.891,which was higher than those of the two separate diagnoses(Zcombination-TBARS=2.911,P=0.004;Zcombination-8-OHdG=2.575,P=0.010).Conclusion The serum TBARS and 8-OHdG levels were elevated in patients with depression and intricately related to the degree of depression and cognitive dysfunction.
