Anesthetic and analgesic effect of perioperative administration of esketamine in patients undergoing off-pump coronary artery bypass grafting
10.12007/j.issn.0258-4646.2025.11.006
- VernacularTitle:围手术期应用艾司氯胺酮在非体外循环冠状动脉旁路移植术患者中的麻醉和镇痛效果
- Author:
Yiou WANG
1
;
Ying WANG
1
;
Yugang DIAO
1
;
Xiaoyu CHEN
1
Author Information
1. 中国人民解放军北部战区总医院麻醉科,沈阳 110016
- Publication Type:Journal Article
- Keywords:
esketamine;
anesthesia;
off-pump coronary artery bypass grafting
- From:
Journal of China Medical University
2025;54(11):995-999
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze anesthetic and analgesic effect of perioperovtive administration of esketamine in patients undergoing off-pump coronary artery bypass grafting(OPCABG).Methods The clinical data of 120 patients who underwent OPCABG under gene-ral anesthesia were retrospectively collected.Patients were divided into an esketamine group(n=60)and a non-esketamine group(n=60)according to whether esketamine was used perioperatively.The patients in the esketamine group received esketamine(1 mg/kg)during anesthesia induction and postoperative patient-controlled analgesia with sufentanil(3 μg/kg)plus esketamine(2 mg/kg).Those in the non-esketamine group received sufentanil(2 μg/kg)during anesthesia induction and postoperative patient-controlled analgesia with sufentanil(3 μg/kg).The mean arterial pressure(MAP)and heart rate(HR)were recorded at the time point of entering the room(T0),after anesthesia induction/before intubation(T1),1 min after intubation(T2),skin incision(T3),sternotomy(T4),after surgery and skin suture(T5),entering the ICU(T6),extubation(T7),24 hours after surgery(T8),and 48 hours after surgery(T9).The extubation time,Ramsay sedation scores,visual analog scale(VAS)scores,and adverse reactions were compared.Results There were no statistically significant differences in the baseline characteristics and MAP and HR at T0 and T1 between the two groups(P＞0.05).From T2 to T9,MAP and HR in the esketamine group were significantly lower than those in the non-esketamine group(P＜0.05).The postoperative extubation time,Ramsay sedation score,and VAS score were significantly lower in the esketamine group than in the non-esketamine group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The perio-perative administration of esketamine in OPCABG can stabilize the hemodynamics,shorten the extubation time,and promote the recovery of patients undergoing OPCABG without increasing postoperative adverse reactions.
