Role of gut microbiota-mediated gut-liver axis in hepatocellular carcinoma
10.12007/j.issn.0258-4646.2025.11.001
- VernacularTitle:肠道菌群介导的肠-肝轴在肝细胞癌中的作用
- Author:
Shuairan ZHANG
1
;
Yiling LI
1
Author Information
1. 中国医科大学附属第一医院消化内科,沈阳 110001
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
gut microbiota;
gut-liver axis;
mycrobiota dysbiosis;
early screening;
therapeutic intervention
- From:
Journal of China Medical University
2025;54(11):961-966,987
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma(HCC)is a common and lethal malignant tumor.Recently,the role of the gut microbiota-mediated gut-liver axis in HCC has attracted widespread attention.Gut microbiota dysbiosis could reportedly promote HCC onset and progression through mechanisms such as inflammatory response induction,immune reaction regulation,and metabolic reprogramming.Specific alte-rations in gut microbiota composition demonstrate a potential diagnostic value for early HCC screening.Furthermore,gut microbiota can significantly influence postoperative recovery and comprehensive treatment responses in patients with HCC,suggesting that the gut micro-biota could serve as a potential target for HCC therapy.Currently,interventional strategies such as dietary adjustments,probiotics/prebio-tics,and fecal microbiota transplantation show promise for improving the gut-liver microenvironment,enhancing treatment sensitivity,and delaying disease progression.In this review,we systematically elaborate on recent research advances concerning the role of gut microbiota in HCC pathogenesis,early diagnosis,and therapeutic intervention,aiming to provide a theoretical basis and novel strategies for the com-prehensive HCC prevention and management.
