Research progress in congenital Zika syndrome
10.3969/j.issn.1002-2694.2025.00.160
- VernacularTitle:先天性寨卡综合征研究进展
- Author:
Yiteng ZHANG
1
;
Zhe LI
1
;
Shengnan WANG
1
;
Wei YANG
1
;
Wei WANG
1
Author Information
1. 中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,呼吸和共病全国重点实验室,国家动物模型技术创新中心,北京协和医学院病原体感染防控教育部重点实验室,北京 100021
- Publication Type:Journal Article
- Keywords:
Zika virus;
congenital Zika syndrome;
blood-brain barrier;
neurodevelopment
- From:
Chinese Journal of Zoonoses
2025;41(10):1089-1094
- CountryChina
- Language:Chinese
-
Abstract:
Zika virus(ZIKV),a flavivirus transmitted primarily through the bites of Aedes mosquitoes,led to a major public health crisis in the 2015 Brazilian outbreak.The World Health Organization(WHO)subsequently designated the Brazilian ZIKV epi-demic as a Public Health Emergency of International Concern(PHEIC)in 2016,because of its devastating consequences.Congenital Zika syndrome(CZS),a distinctive constellation of teratogenic effects caused by intrauterine ZIKV infection,is characterized by mi-crocephaly,ocular lesions,cortical calcifications,congenital contractures,and multisystem developmental anomalies.CZS poses sub-stantial risks to neonatal survival and long-term health outcomes.Despite containment efforts,ZIKV remains prevalent across multiple endemic regions,thus underscoring persistent threats to maternal-fetal health.Systematic longitudinal monitoring of CZS cohorts,inte-grated with interdisciplinary approaches bridging clinical assessments and mechanistic studies,is imperative to elucidate the pathogen-esis and advance therapeutic strategies.To inform future investigations and identify novel research directions in CZS pathobiology,this review synthesizes recent advances in three key domains:clinical characterization of CZS manifestations,development of CZS animal models,and breakthroughs in molecular mechanisms underlying ZIKV-induced teratogenesis.
