Research progress in vaccine lipid delivery systems and their tuberculosis DNA vaccine applications
10.3969/j.issn.1002-2694.2025.00.172
- VernacularTitle:疫苗脂质载体递送系统研究进展及其在结核DNA疫苗中的应用
- Author:
Danyang ZHANG
1
;
Yan LIANG
1
Author Information
1. 中国人民解放军总医院第八医学中心结核病医学部研究所,结核病诊疗新技术北京市重点实验室,北京 100091
- Publication Type:Journal Article
- Keywords:
tuberculosis;
DNA vaccines;
lipid carrier;
pulmonary delivery;
mechanism of action
- From:
Chinese Journal of Zoonoses
2025;41(10):1069-1072
- CountryChina
- Language:Chinese
-
Abstract:
Vaccines are essential in the field of infectious diseases,but their applications have multiple limitations.DNA vac-cines have attracted substantial attention for their low cost and easy storage;however,their direct immune effects areunsatisfactory.Therefore,an urgent need exists to develop safer and more efficient delivery systems.As a chronic infectious disease,tuberculosis,particularly the widespread prevalence of pulmonary tuberculosis,has attracted increasing attention in the prevention and treatment of respiratory diseases.Nanocarrier technology has opened a new path for gene therapy and the application of biological nanomaterials.Lipid nanocarriers are considered ideal vaccine delivery media,because their unique physical and chemical properties can signifi-cantly decrease the toxic side effects of drugs,and achieve sustained and controlled drug release.This article reviews the advantages,applications,and mechanisms of lipid carriers as DNA vaccine delivery media,to provide theoretical support for the development of new tuberculosis vaccine delivery systems in the future.
