NT-proBNP Is an Important Indicator for Predicting Heart Failure after Acute Myocardial Infarction
10.11969/j.issn.1673-548X.2025.02.027
- VernacularTitle:NT-proBNP是预测心肌梗死后心力衰竭的重要指标
- Author:
Ruifeng LIU
1
;
Xiangyu GAO
1
;
Jihong FAN
1
Author Information
1. 100050 首都医科大学附属北京友谊医院心血管中心
- Publication Type:Journal Article
- Keywords:
N-terminal pro-B-type natriuretic peptide;
Acute myocardial infarction;
Left ventricular ejection fraction;
Restrict-ed cubic spline
- From:
Journal of Medical Research
2025;54(2):172-176,187
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the peak levels of N-terminal pro-B-type natriuretic peptide(NT-proBNP)during hospitalization and the risk of left ventricular ejection fraction(LVEF)＜50％during the recovery period in pa-tients with acute myocardial infarction(AMI).Methods This retrospective cohort study included 220 AMI patients treated at Beijing Friendship Hospital,Capital Medical University from January 2018 to December 2023.The patients were divided into three groups accord-ing to the tripartite value of peak levels of NT-proBNP during hospitalization.Baseline clinical characteristics,laboratory test results,and peak levels of NT-proBNP were collected.The primary outcome was LVEF＜50％during the recovery period.By incorporating con-founding factors,three stepwise complex Logistic regression model and linear regression model were used to analyze the relationship be-tween peak levels of NT-proBNP and the risk of LVEF＜50％.Restricted cubic spline(RCS)was used to explore the nonlinear relation-ship between them.Results The peak levels of NT-proBNP were positively correlated with an increased risk of LVEF＜50％during the recovery period,even after adjusting for confounding factors.RCS analysis revealed the nonlinear relationships between them.When the peak levels of NT-proBNP was 1822.991pg/ml,the sensitivity and specificity of predicting LVEF＜50％were 57.14％and 70.97％.Conclusion The NT-proBNP peak levels of 1822.991 pg/ml is a useful indicator for predicting LVEF＜50％in AMI pa-tients during the recovery period,and it can be used to identify high-risk AMI groups and provide basis for early active intervention.
