Application Value of TIR Combined with SII in Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus
10.11969/j.issn.1673-548X.2025.02.026
- VernacularTitle:TIR联合SII炎性指数在2型糖尿病患者颈动脉粥样硬化中的应用价值
- Author:
Xuefei YU
1
;
Yingzhi HUANG
1
Author Information
1. 234000 宿州,蚌埠医科大学附属皖北煤电集团总医院内分泌科
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Carotid atherosclerosis;
Time in range;
Systemic immune-inflammation index
- From:
Journal of Medical Research
2025;54(2):166-171
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application value of glucose time in range(TIR)combined with systemic immune-inflam-mation index(SII)in diagnosing the occurrence of carotid atherosclerosis(CAS)in patients with type 2 diabetes mellitus(T2DM).Methods Using a retrospective study method,a total of 247 patients with T2DM were admitted to the Wan Bei General Hospital of Wan-bei Coal Power Group of Bengbu Medical University from August 2022 to April 2024,which were selected and divided into non-CAS group(n=106)and CAS group(n=141)according to the results of carotid ultrasound;the general data of all patients,biochemical and blood routine indexes,and continuous glucose monitoring(CGM)parameters were retrospectively collected and statistically analyzed;the differences in the indexes between the two groups were compared,and multivariate Logistic regression analysis was used to screen the inde-pendent risk factors for CAS in T2DM patients,and the value of TIR,SII and their combination in diagnosing CAS in T2DM patients were evaluated by drawing the receiver operating characteristic(ROC)curve.Results Compared with the patients in the non-CAS group,the TIR level was significantly lower and the SII level was significantly higher in the CAS group,and the differences were statistically sig-nificant(P＜0.001);The multivariate Logistic regression analysis results showed that age,systolic blood pressure,TIR and SII were the independent risk factors for the occurrence of CAS in T2DM patients(OR were 1.120,1.029,-0.962,1.003,P＜0.01).ROC curve analysis showed that the area under the curve(AUC)of TIR was 0.697,with an optimal cut-off value of 82.6％;The AUC of SII was 0.672,with an optimal cut-off value of 384.147;The AUC of the combined detection was 0.740,which was superior to that of single detection(P＜0.01).Conclusion TIR and SII were significantly correlated with the thickening of the carotid artery intima-media thickness in patients with T2DM,the decreased TIR and elevated SII are independent risk factors for the complication of CAS in patients with T2DM,and the combined diagnosis of the two can improve the predictive value of the occurrence of CAS in patients with T2DM.
