Brucellosis and tuberculosis:comparative analysis of clinical characteristics and features of co-infection
10.3969/j.issn.1002-2694.2025.00.163
- VernacularTitle:布鲁菌病与结核病:临床特征的异同比对及合并感染的特征分析
- Author:
Yilin WANG
1
;
Zihan TANG
;
Yuanyuan SHANG
;
Yu PANG
;
Jun FAN
Author Information
1. 首都医科大学附属北京胸科医院/北京市结核病胸部肿瘤研究所细菌免疫学实验室/耐药结核病研究北京市重点实验室,北京 101149
- Publication Type:Journal Article
- Keywords:
brucellosis;
tuberculosis;
complications;
clinical manifestations
- From:
Chinese Journal of Zoonoses
2025;41(10):1055-1060
- CountryChina
- Language:Chinese
-
Abstract:
This study compared the clinical characteristics of brucellosis,tuberculosis,and their co-infections,to improve dif-ferential diagnosis and disease management.A retrospective analysis was conducted on 41 patients with brucellosis,38 co-infected pa-tients,and 95 patients with tuberculosis admitted to Beijing Chest Hospital,Capital Medical University,between January 2017 and December 2024.Clinical manifestations,laboratory findings,and complications were analyzed statistically.Brucellosis and tuberculo-sis shared clinical similarities,such as presentation with prolonged fever.However,patients with brucellosis tended to exhibit muscle pain,night sweats,and loss of appetite,whereas patients with tuberculosis frequently presented with cough,sputum production,and lymphadenopathy.Co-infected patients had a higher fever incidence,and elevated hs-CRP and ESR levels.Whereas spinal spondyli-tis was more frequent in brucellosis,pulmonary infections and pleural effusion were predominant in tuberculosis.Co-infected patients exhibited characteristics of both diseases,and showed more severe systemic inflammation and prolonged illness.In conclusion,al-though elevated hs-CRP and ESR might aid in differentiation,pathogen detection is crucial for accurate diagnosis.Strengthening screening in patients with persistent fever and systemic inflammation may improve early identification,optimize treatment,and en-hance outcomes.
