Progress in interplay between human papillomavirus and tumor immune microenvironment of head and neck squamous cell carcinoma
10.3969/j.issn.1000-4718.2025.02.024
- VernacularTitle:人乳头瘤病毒与头颈部鳞癌肿瘤免疫微环境相互作用的研究进展
- Author:
Lingnan ZHANG
1
;
Siyuan ZHOU
;
Xiaoyan LIU
;
Jing WANG
Author Information
1. 滨州医学院附属医院口腔正畸科,山东 滨州 256600
- Publication Type:Journal Article
- Keywords:
human papillomavirus;
head and neck squamous cell carcinoma;
tumor immune microenviron-ment;
immunotherapy;
prognosis
- From:
Chinese Journal of Pathophysiology
2025;41(2):403-411
- CountryChina
- Language:Chinese
-
Abstract:
Head and neck squamous cell carcinoma(HNSCC)is currently acknowledged as an independent cause of disease.Beyond smoking and heavy alcohol use,persistent infection with high-risk human papillomavirus(HPV)is receiving increased recognition as a newly identified independent cause of this condition.The distinct clinical character-istics of HPV-related HNSCC,which are linked with a better prognosis,and its interaction with the tumor immune micro-environment,are areas of intense research focus.The specific immune response triggered by HPV and the tumor immune microenvironment are vital in the development,progression,and outcome of HNSCC.This review examines the ways HPV positive HNSCC evades the immune system,assesses the influence of HPV on the tumor immune microenvironment in HN-SCC,and explores its interaction with the body's adaptive immunity.This article presents a review on the evaluation of specific immune responses in improving the prognosis of HPV-related HNSCC and discusses the potential value of immune analysis in predicting prognosis.Furthermore,we analyze novel immune therapy strategies,mechanisms,and prognosis in HPV-related HNSCC.
