Association between Monocyte-to-high-density lipoprotein cholesterol Ratio and Sarcopenia
10.11969/j.issn.1673-548X.2025.02.023
- VernacularTitle:单核细胞与高密度脂蛋白胆固醇比值与肌肉减少症的关联
- Author:
Feng CUI
1
;
Chen MI
1
;
Yuanhua SHE
1
Author Information
1. 730030 兰州大学第二医院(第二临床医学院)普外科
- Publication Type:Journal Article
- Keywords:
Sarcopenia;
Monocyte-to-high-density lipoprotein cholesterol ratio;
Cross-sectional study
- From:
Journal of Medical Research
2025;54(2):147-151,158
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between the monocyte-to-high-density lipoprotein cholesterol ratio(MHR)and sarcopenia in an adult population.Methods A cross-sectional study was conducted with 8085 participants aged 20 years and older,selected from four cycles(2011-2018)of the National Health and Nutrition Examination Survey(NHANES).Multivariate Logistic re-gression model was used to evaluate the association between MHR and sarcopenia.Variance inflation factors(VIF)were calculated to as-sess multicollinearity between variables.Restricted cubic splines were employed to explore nonlinear relationships,with interaction tests and subgroup analyses performed as well.Results In the fully adjusted model,MHR was positively associated with sarcopenia(OR=2.56,95％CI:1.73-3.79,P＜0.001).This association was more pronounced in participants with smoking history and cardiovascular disease.Additionally,restricted cubic spline analysis indicated a linear relationship between MHR and sarcopenia.Conclusion MHR is positively associated with the risk of sarcopenia and may serve as a potential early indicator for identifying sarcopenia.
