Tuberculosis epidemiology and drug resistance characteristics in a designated tuberculosis hospital in Hunan Province in 2024
10.3969/j.issn.1002-2694.2025.00.170
- VernacularTitle:2024年湖南某结核病定点医院结核病流行病学和耐药特征分析
- Author:
Jixiang LI
1
;
Jingwei GUO
;
Xinyue HE
;
Ruihuan WANG
;
Xiuqin ZHAO
;
Machao LI
;
Guilian LI
;
Lili ZHAO
;
Ruibai WANG
;
Jue WANG
;
Jie DUAN
;
Kanglin WAN
;
Xiuqin YUAN
;
Haican LIU
Author Information
1. 南华大学公共卫生学院,衡阳 421001;传染病溯源预警与智能决策全国重点实验室,中国疾病预防控制中心传染病预防控制所,北京 102206
- Publication Type:Journal Article
- Keywords:
Mycobacterium tuberculosis;
drug resistance;
associated factors;
mutation;
lineage
- From:
Chinese Journal of Zoonoses
2025;41(10):1040-1047
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed at analyzing the epidemiological and drug resistance characteristics of tuberculosis at a desig-nated tuberculosis hospital in Hunan Province in 2024.Patients diagnosed with TB at the hospital between April and October 2024 were included in the study.Demographic data,clinical information,and drug sensitivity test results were collected from the hospital′s electronic medical record system.Descriptive statistics,the chi-square test,and logistic regression were used to analyze the epidemic characteristics,drug resistance characteristics,and factors influencing tuberculosis.Whole genome sequencing of isolates was per-formed,and lineage classification and drug resistance gene mutations were detected with TB-Profiler.The male-to-female ratio was 2.72∶1,and the median age was 56(IQR:43-66)years.Among the 391 patients,most were farmers(46.8%,183/391)and were pri-marily from Changsha(41.1%,162/391).Significant differences were observed in sex and occupation between pulmonary tuberculosis(PTB)and extrapulmonary tuberculosis(EPTB).The overall prevalence of any type of drug resistance of tuberculosis was 33.25%,and the multidrug resistance TB(MDR-TB)and poly-drug resistance(PR-TB)rates were 14.23%and 4.35%,respectively.The re-sistance rates to rifampicin(RIF),isoniazid(INH),ethambutol(EMB),and streptomycin(SM)were 17.90%,22.25%,6.39%,and 20.20%,respectively.Multivariable logistic regression analysis indicated that both diabetes(OR:2.295,95%CI:1.082-4.866)and retreatment(OR:17.822,95%CI:8.343-38.072)were risk factors for developing MDR-TB.Lineage 2(L2)strains accounted for 64.40%(136/191),whereas lineage 4(L4)accounted for 28.80%(55/191).The most common drug resistance mutations were katG Ser315Thr(62.50%,20/32)for INH,rpoB Ser450Leu(50.00%,12/24)for RIF,embB Met306Val(55.56%,5/9)for EMB,and rpsL Lys43Arg(80.95%,34/42)for SM.In conclusion,TB drug resistance was found to be a serious problem at a designated tu-berculosis hospital in Hunan in 2024.Strengthening the treatment and management of patients infected with L2 strains,those with co-morbid diabetes,and retreatment cases is crucial for preventing and controlling the emergence of drug-resistant TB.
