Comparison of Prognosis between Differentiated and Common Bladder Urothelial Carcinoma
10.11969/j.issn.1673-548X.2025.02.018
- VernacularTitle:分化型与普通型膀胱尿路上皮癌预后情况比较
- Author:
Yuan SHUI
1
;
Longhui LAI
1
;
Wentao MA
1
Author Information
1. 730030 兰州大学第二医院(兰州大学第二临床医学院)泌尿外科
- Publication Type:Journal Article
- Keywords:
Common type uroepithelial carcinoma;
Differentiated uroepithelial carcinoma;
Propensity score matching;
Survival;
Mortality risk
- From:
Journal of Medical Research
2025;54(2):110-116
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the prognosis of differentiated bladder urothelial carcinoma(BUC)and common BUC.Methods A retrospective study was conducted to select the clinical data of 236 patients with common BUC and 40 patients with differentiated BUC who underwent radical cystectomy for muscular invasive bladder cancer from January 2012 to March 2023 in the Second Hospital of Lanzhou University.A propensity score matching(PSM)method was used to reduce selection bias in observational studies.The Kaplan-Meier method was used to compare overall survival(OS)and disease-specific survival(CSS)between the two groups.The COX propor-tional risk model was used to analyze the effect of differentiated BUC on overall mortality risk(OMR)and cancer-specific mortality risk(CSMR).Results The median follow-up time was 30.5months,ranged from 4months to 134months.Before PSM,there were signifi-cant differences in overall mortality(OM)and cancer-specific mortality(CSM)between the differentiated BUC and the common BUC(P were 0.008,0.011).The Kaplan-Meier survival curve analysis showed the OS(P=0.020)and CSS(P=0.023)of common BUC were better than those of differentiated BUC.Multivariate COX regression analysis showed that the OMR and CSMR of differentiated BUC increased by 75％(P=0.013)and 79％(P=0.029)compared with common BUC.After PSM,there was no significant difference in OM(P=0.217)and CSM(P=0.134)between the two groups.Kaplan-Meier survival curve analysis showed that there was no signifi-cant difference in OS(P=0.510)and CSS(P=0.340)between common BUCand differentiated BUC.Multivariate COX regression a-nalysis showed that there were no significant differences in OMR and CSMR between the two groups(all P＞0.05).Conclusion After PSM,the prognosis of differentiated BUC was not found to be inferior to that of the common BUC.Furthermore,the specific type of differ-entiation was not identified as an individual predictor of a worse prognosis.
