Meta-analysis of Quantitative and Qualitative Multi-parameter MRI Analysis to Predict the Efficacy of Neoadjuvant Chemotherapy for Breast Cancer
10.11969/j.issn.1673-548X.2025.02.017
- VernacularTitle:多参数MRI定量及定性分析预测乳腺癌新辅助化疗疗效的Meta分析
- Author:
Ting YANG
1
;
Xuewen LIU
1
;
Juan YAO
1
Author Information
1. 832001 乌鲁木齐,新疆医科大学第一附属医院影像中心
- Publication Type:Journal Article
- Keywords:
Multi-parameter magnetic resonance imaging;
Breast cancer;
Neoadjuvant chemotherapy;
Meta-analysis
- From:
Journal of Medical Research
2025;54(2):103-109
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the morphological characteristics of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)and diffusion-weighted imaging(DWI),and the diagnostic performance of quantitative and qualitative parameters in the diagnosis of neoadjuvant chemotherapy for breast cancer.Methods The database of PubMed,EMBASE,Cochrane Library,Web of Sci-ence,CNKI and Wanfang Data Knowledge Service Platform databases were searched.The search period was from January 2014 to July 2024.QUADAS-2 was used to evaluate the methodological quality of included studies.Data were extracted,and the data of true posi-tive,false positive,true negative and false negative were sorted out,and the sensitivity,specificity,positive predictive value(PLR)and negative predictive value(NLR)were calculated.Data merging,heterogeneity test,Meta regression analysis and subgroup analysis were performed using Stata 13.0 and RevMan 5.3.Results A total of 2244 breast cancer patients with an average age of 49.2 years were in-cluded in 17 literatures according to the inclusion and exclusion criteria.The sensitivity,specificity,PLR and NLR of DCE-MRI were 80％,75％,3.20,0.27,respectively.The sensitivity,specificity,PLR and NLR of DWI were 81％,64％,2.30,0.29,respectively.Subgroup analysis showed that magnetic field intensity had an effect on heterogeneity,but age,study design and different evaluation pa-rameters had no significant effect on heterogeneity.Conclusion There is no significant difference between DCE-MRI and DWI in the diagnostic efficacy of neoadjuvant chemotherapy for breast cancer.When patients are unable to undergo DCE-MRI,DWI can be a poten-tial non-invasive alternative examination.
