Influence of cathepsin K on periodontitis and periodontal regeneration
10.3969/j.issn.1000-4718.2024.00.026
- VernacularTitle:组织蛋白酶K对牙周炎发展和牙周再生的影响
- Author:
Weiting MAO
1
;
Ruoqi ZHANG
1
;
Yuewen ZHAO
1
;
Shan HUANG
1
Author Information
1. 暨南大学附属第一医院口腔医院,暨南大学口腔交叉学科临床研究平台,暨南大学口腔医学院,广东 广州 510632
- Publication Type:Journal Article
- Keywords:
periodontitis;
cathepsin K;
bone resorption;
biomarkers;
inhibitor
- From:
Chinese Journal of Pathophysiology
2025;41(2):388-393
- CountryChina
- Language:Chinese
-
Abstract:
Periodontitis is a chronic inflammatory disease primarily triggered by dysregulation of microbial communities and altered host immune response.It is clinically presented by alveolar bone resorption,which is one of the main causes of loosening of teeth and tooth loss.Cathepsin K(CTSK)is a highly expressed collagenase produced by osteo-clasts and can directly degrade matrix collagen proteins and indirectly increase osteoclast activity.The expression level of CTSK fluctuates in response to the progression of periodontal inflammation.The expression of Toll-like receptors is upregu-lated in periodontitis lesions.Pathogen-associated molecular pattern binds to relevant TLRs,initiating downstream im-mune pathways that promote receptor activator of nuclear factor-κB ligand-dependent osteoclastogenesis,along with in-creased expression of CTSK.Intervening in the process of alveolar bone resorption can be achieved through the regulation of CTSK.This paper provides a summary of the pathogenic mechanism of CTSK in periodontitis and highlights the research progress regarding the use of CTSK as a therapeutic target.The aim is to offer insights and references for the treatment of periodontitis.
